HMOX2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P30519 |
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Clone Names | 100507306 |
Gene ID | 3163 |
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Other Names | Heme oxygenase 2, HO-2, HMOX2, HO2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | HMOX2 |
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Synonyms | HO2 |
Function | [Heme oxygenase 2]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. |
Cellular Location | Microsome membrane; Single-pass type IV membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:P09601}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P09601}; Single-pass type IV membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:P09601} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Heme oxygenase, an essential enzyme in heme catabolism,cleaves heme to form biliverdin, which is subsequently converted tobilirubin by biliverdin reductase, and carbon monoxide, a putativeneurotransmitter. Heme oxygenase activity is induced by itssubstrate heme and by various nonheme substances. Heme oxygenaseoccurs as 2 isozymes, an inducible heme oxygenase-1 and aconstitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the hemeoxygenase family. Alternative splice variants encoding the sameprotein have been identified at this locus.
References
Abdel Aziz, M.T., et al. Andrologia 42(4):236-241(2010)Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)He, J.Z., et al. J. Biol. Chem. 285(13):9452-9461(2010)Zhong, J.L., et al. Free Radic. Biol. Med. 48(2):196-206(2010)Yun, L., et al. Clin. Exp. Hypertens. 31(7):534-543(2009)
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