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Mouse Ctsl1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P06797
Clone Names 110919084
Additional Information
Gene ID 13039
Other Names Cathepsin L1, Cathepsin L, Major excreted protein, MEP, p39 cysteine proteinase, Cathepsin L1 heavy chain, Cathepsin L1 light chain, Ctsl, Ctsl1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ctsl {ECO:0000312|MGI:MGI:88564}
Synonyms Ctsl1
Function Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:12782676). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (PubMed:12869695). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells (PubMed:12021314). Also mediates invariant chain processing in cortical thymic epithelial cells (PubMed:9545226). Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (PubMed:12417635). Secreted form generates endostatin from COL18A1 (PubMed:10716919). Critical for cardiac morphology and function (PubMed:11972068). Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (PubMed:12163394). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity).
Cellular Location Lysosome. Apical cell membrane; Peripheral membrane protein; Extracellular side. Secreted, extracellular space. Secreted Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250|UniProtKB:P25975}. Note=Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages (PubMed:12417635)
Tissue Location Expressed in thymus, kidney and liver (PubMed:9545226). Expressed in thyroid epithelial cells. Expressed in cortical thymic epithelial cells (PubMed:9545226). Expressed by antigen presenting cells (APCs) such as dendritic cells and macrophages (PubMed:11483509, PubMed:12417635).
Research Areas
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Background

Important for the overall degradation of proteins in lysosomes.

References

Zeeuwen, P.L., et al. FASEB J. 24(10):3744-3755(2010)Shimada, N., et al. Am. J. Pathol. 176(5):2571-2580(2010)Duewell, P., et al. Nature 464(7293):1357-1361(2010)Ceru, S., et al. J. Biol. Chem. 285(13):10078-10086(2010)Gocheva, V., et al. Genes Dev. 24(3):241-255(2010)

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$ 277.78
Cat# BP19338b
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