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mouse Grin2a Antibody (Center K1081) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P35436
Clone Names 111205020
Additional Information
Gene ID 14811
Other Names Glutamate receptor ionotropic, NMDA 2A, GluN2A, Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, NMDAR2A, NR2A, Grin2a
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Grin2a
Function Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium (PubMed:1374164). Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (By similarity). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (PubMed:7816096, PubMed:8987814).
Cellular Location Cell projection, dendritic spine. Cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:Q00959}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q00959}. Cytoplasmic vesicle membrane. Note=Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex.
Tissue Location Detected in striatum (PubMed:28469074). Detected in forbrain (PubMed:7816096). Detected in cerebellum (at protein level) (PubMed:8987814). Detected in brain cortex, piriform cortex, hippocampus, caudate-putamen, dentate gyrus and granule cell layer (PubMed:1374164, PubMed:7816096).
Research Areas
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Background

NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.

References

Fan, J., et al. J. Neurochem. 115(4):1045-1056(2010)Ohno, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(34):15252-15257(2010)Jin, S.X., et al. PLoS ONE 5 (7), E11732 (2010) :Tang, T.T., et al. Proc. Natl. Acad. Sci. U.S.A. 106(50):21395-21400(2009)Taniguchi, S., et al. EMBO J. 28(23):3717-3729(2009)

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$ 277.78
Cat# BP19357c
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