|Other Names||Transmembrane protease serine 6, 3421-, Matriptase-2, TMPRSS6|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Note=The processed, activated two-chains form is released in the extracellular space|
|Tissue Location||Liver specific..|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a type IItransmembrane serine proteinase that is found attached to the cellsurface. The encoded protein may be involved in matrix remodelingprocesses in the liver.
Altamura, S., et al. Biochem. J. 431(3):363-371(2010)Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)De Falco, L., et al. Hum. Mutat. 31 (5), E1390-E1405 (2010) :Tanaka, T., et al. Blood 115(1):94-96(2010)Lee, P. Acta Haematol. 122 (2-3), 87-96 (2009) :
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