CDK2AP2 Antibody(Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O75956 |
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Clone Names | 100603320 |
Gene ID | 10263 |
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Other Names | Cyclin-dependent kinase 2-associated protein 2, CDK2-associated protein 2, DOC-1-related protein, DOC-1R, CDK2AP2, DOC1R |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CDK2AP2 |
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Synonyms | DOC1R |
Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:33283408). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148). Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs (By similarity). Regulates microtubule organization of metaphase II oocytes (By similarity). |
Cellular Location | Cytoplasm. Nucleus Note=Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules {ECO:0000250|UniProtKB:Q9CPY4} |
Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Belongs to the CDK2AP family.
References
Buajeeb, W., et al. Biochem. Biophys. Res. Commun. 315(4):998-1003(2004)Zhang, X., et al. Biochem. Biophys. Res. Commun. 255(1):59-63(1999)
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