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CDK2AP2 Antibody(Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession O75956
Clone Names 100603320
Additional Information
Gene ID 10263
Other Names Cyclin-dependent kinase 2-associated protein 2, CDK2-associated protein 2, DOC-1-related protein, DOC-1R, CDK2AP2, DOC1R
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDK2AP2
Synonyms DOC1R
Function Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:33283408). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148). Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs (By similarity). Regulates microtubule organization of metaphase II oocytes (By similarity).
Cellular Location Cytoplasm. Nucleus Note=Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules {ECO:0000250|UniProtKB:Q9CPY4}
Tissue Location Ubiquitous..
Research Areas
Citations (0)
citation

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Background

Belongs to the CDK2AP family.

References

Buajeeb, W., et al. Biochem. Biophys. Res. Commun. 315(4):998-1003(2004)Zhang, X., et al. Biochem. Biophys. Res. Commun. 255(1):59-63(1999)

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$ 277.78
Cat# BP19378c
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