|Other Names||Splicing factor 3B subunit 4, Pre-mRNA-splicing factor SF3b 49 kDa subunit, SF3b50, Spliceosome-associated protein 49, SAP 49, SF3B4, SAP49|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well (PubMed:10882114). Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of four subunits of the splicingfactor 3B. The protein encoded by this gene cross-links to a regionin the pre-mRNA immediately upstream of the branchpoint sequence inpre-mRNA in the prespliceosomal complex A. It also may be involvedin the assembly of the B, C and E spliceosomal complexes. Inaddition to RNA-binding activity, this protein interacts directlyand highly specifically with subunit 2 of the splicing factor 3B.This protein contains two N-terminal RNA-recognition motifs (RRMs),consistent with the observation that it binds directly to pre-mRNA.
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)Rikova, K., et al. Cell 131(6):1190-1203(2007)Watanabe, H., et al. J. Biol. Chem. 282(28):20728-20738(2007)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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