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SF3B4 Antibody(Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q15427
Clone Names 100525304
Additional Information
Gene ID 10262
Other Names Splicing factor 3B subunit 4, Pre-mRNA-splicing factor SF3b 49 kDa subunit, SF3b50, Spliceosome-associated protein 49, SAP 49, SF3B4, SAP49
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SF3B4
Synonyms SAP49
Function Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well (PubMed:10882114). Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077).
Cellular Location Nucleus
Research Areas
Citations (0)

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Background

This gene encodes one of four subunits of the splicingfactor 3B. The protein encoded by this gene cross-links to a regionin the pre-mRNA immediately upstream of the branchpoint sequence inpre-mRNA in the prespliceosomal complex A. It also may be involvedin the assembly of the B, C and E spliceosomal complexes. Inaddition to RNA-binding activity, this protein interacts directlyand highly specifically with subunit 2 of the splicing factor 3B.This protein contains two N-terminal RNA-recognition motifs (RRMs),consistent with the observation that it binds directly to pre-mRNA.

References

Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)Rikova, K., et al. Cell 131(6):1190-1203(2007)Watanabe, H., et al. J. Biol. Chem. 282(28):20728-20738(2007)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

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$ 277.78
Cat# BP19396c
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