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ILKAP Antibody(Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H0C8
Clone Names 100603101
Additional Information
Gene ID 80895
Other Names Integrin-linked kinase-associated serine/threonine phosphatase 2C, ILKAP, ILKAP
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ILKAP
Function Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.
Cellular Location Cytoplasm.
Tissue Location Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a proteinserine/threonine phosphatase of the PP2C family. This protein caninteract with integrin-linked kinase (ILK/ILK1), a regulator ofintegrin mediated signaling, and regulate the kinase activity ofILK. Through the interaction with ILK, this protein may selectivelyaffect the signaling process of ILK-mediated glycogen synthasekinase 3 beta (GSK3beta), and thus participate in Wnt signalingpathway.

References

Nakrieko, K.A., et al. Cell Cycle 7(14):2157-2166(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Hillier, L.W., et al. Nature 434(7034):724-731(2005)Kumar, A.S., et al. Oncogene 23(19):3454-3461(2004)

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$ 277.78
Cat# BP19399c
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