|Other Names||Disks large homolog 3, Neuroendocrine-DLG, Synapse-associated protein 102, SAP-102, SAP102, XLMR, DLG3, KIAA1232|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.|
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This gene encodes a member of the membrane-associatedguanylate kinase protein family. The encoded protein may play arole in clustering of NMDA receptors at excitatory synapses. It mayalso negatively regulate cell proliferation through interactionwith the C-terminal region of the adenomatosis polyposis coli tumorsuppressor protein. Mutations in this gene have been associatedwith X-linked mental retardation. Alternatively spliced transcriptvariants have been described.
Bailey, S.D., et al. Diabetes Care (2010) In press :Zanni, G., et al. Neurogenetics 11(2):251-255(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Gill, M.B., et al. J. Biol. Chem. 284(21):14503-14512(2009)Rikova, K., et al. Cell 131(6):1190-1203(2007)
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