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DHODH Antibody(Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q02127 |
|---|---|
| Clone Names | 100712065 |
| Gene ID | 1723 |
|---|---|
| Other Names | Dihydroorotate dehydrogenase (quinone), mitochondrial, DHOdehase, Dihydroorotate oxidase, DHODH |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DHODH |
|---|---|
| Function | Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway. |
| Cellular Location | Mitochondrion inner membrane; Single-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene catalyzes the fourthenzymatic step, the ubiquinone-mediated oxidation of dihydroorotateto orotate, in de novo pyrimidine biosynthesis. This protein is amitochondrial protein located on the outer surface of the innermitochondrial membrane.
References
Hail, N. Jr., et al. Free Radic. Biol. Med. 49(1):109-116(2010)Ng, S.B., et al. Nat. Genet. 42(1):30-35(2010)Grabar, P.B., et al. Ann. Rheum. Dis. 68(8):1367-1368(2009)Pawlik, A., et al. Pharmacogenomics 10(2):303-309(2009)Anney, R.J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1369-1378 (2008) :
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