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Mouse Dyrk1a Antibody(C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q61214
Clone Names 110316131
Additional Information
Gene ID 13548
Other Names Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase, MP86, Protein kinase minibrain homolog, MNBH, Dyrk1a, Dyrk
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Dyrk1a
Synonyms Dyrk
Function Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (PubMed:20167603).
Cellular Location Nucleus speckle.
Tissue Location Detected in brain (at protein level). Expressed in a variety of embryonic and adult tissues. Expressed abundantly in neurons of the brain, spinal cord, and retina in developing embryos
Research Areas
Citations (0)

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Background

Dyrk1a may play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.

References

Park, J., et al. J. Biol. Chem. 285(41):31895-31906(2010)Guo, X., et al. J. Biol. Chem. 285(17):13223-13232(2010)Kurabayashi, N., et al. Mol. Cell. Biol. 30(7):1757-1768(2010)Lee, Y., et al. J. Biol. Chem. 284(48):33343-33351(2009)Noll, C., et al. PLoS ONE 4 (10), E7540 (2009) :

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$ 277.78
Cat# BP19429b
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