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ZNF410 Antibody(C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q86VK4 |
|---|---|
| Clone Names | 110717238 |
| Gene ID | 57862 |
|---|---|
| Other Names | Zinc finger protein 410, Another partner for ARF 1, Zinc finger protein APA-1, ZNF410, APA1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZNF410 {ECO:0000303|PubMed:33301730, ECO:0000312|HGNC:HGNC:20144} |
|---|---|
| Function | Transcription factor that binds to the sequence motif 5'- CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33301730, PubMed:33859416). Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33301730, PubMed:33859416). May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (PubMed:12370286). May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (PubMed:30078215). However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (PubMed:33301730, PubMed:33859416). |
| Cellular Location | Nucleus. Chromosome. Note=Directly binds to the sequence motif 5'-CATCCCATAATA-3'. |
| Tissue Location | Widely expressed.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Hubner, R.A., et al. Int. J. Cancer 123(3):586-593(2008)Benanti, J.A., et al. Mol. Cell. Biol. 22(21):7385-7397(2002)
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