|Other Names||Pre-mRNA-processing factor 17, Cell division cycle 40 homolog, EH-binding protein 3, Ehb3, PRP17 homolog, hPRP17, CDC40, EHB3, PRP17, PRPF17|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1947c was selected from the Center region of human PRP17. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||EHB3, PRP17, PRPF17|
|Function||Required for pre-mRNA splicing as component of the activated spliceosome.|
|Cellular Location||Nucleus. Nucleus speckle|
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Provided below are standard protocols that you may find useful for product applications.
Pre-mRNA splicing occurs in two sequential transesterification steps. PRP17 is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. PRP17 has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.
Ben-Yehuda, S., et al., Genetics 156(4):1503-1517 (2000).Lindsey, L.A., et al., J. Biol. Chem. 273(49):32771-32775 (1998).Ben Yehuda, S., et al., RNA 4(10):1304-1312 (1998).Zhou, Z., et al., EMBO J. 17(7):2095-2106 (1998).Salcini, A.E., et al., Genes Dev. 11(17):2239-2249 (1997).
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