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GPR52 Antibody(C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9Y2T5
Clone Names 110811089
Additional Information
Gene ID 9293
Other Names Probable G-protein coupled receptor 52, GPR52
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR52 {ECO:0000303|PubMed:9931487, ECO:0000312|HGNC:HGNC:4508}
Function Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228).
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed in brain, especially in striatum.
Research Areas
Citations (0)

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Background

Members of the G protein-coupled receptor (GPR) familyplay important roles in signal transduction from the externalenvironment to the inside of the cell.

References

Sawzdargo, M., et al. Brain Res. Mol. Brain Res. 64(2):193-198(1999)

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$ 277.78
Cat# BP19491b
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