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ANXA13 Antibody(N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P27216
Clone Names 100603170
Additional Information
Gene ID 312
Other Names Annexin A13, Annexin XIII, Annexin-13, Intestine-specific annexin, ISA, ANXA13, ANX13
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANXA13
Synonyms ANX13
Function [Isoform A]: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner (PubMed:27676605, PubMed:30610115). Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup (PubMed:27676605).
Cellular Location Apical cell membrane. Cell membrane; Lipid-anchor. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q99JG3}. Note=Myristoylation anchors the protein to the membrane, but the protein displays also calcium-dependent, reversible binding to lipid membranes (PubMed:30610115). Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes (PubMed:1530946).
Tissue Location Detected in epithelial cells in colon and jejunum (at protein level). Detected in epithelial cells in jejunum
Research Areas
Citations (0)

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Background

This gene encodes a member of the annexin family. Membersof this calcium-dependent phospholipid-binding protein family playa role in the regulation of cellular growth and in signaltransduction pathways. The specific function of this gene has notyet been determined; however, it is associated with the plasmamembrane of undifferentiated, proliferating endothelial cells anddifferentiated villus enterocytes. Alternatively spliced transcriptvariants encoding different isoforms have been identified.

References

Reiske, H., et al. Anal. Quant. Cytol. Histol. 32(2):61-69(2010)Anderson, N.L., et al. Mol. Cell Proteomics 3(4):311-326(2004)Iglesias, J.M., et al. Mol. Biol. Evol. 19(5):608-618(2002)Noda, Y., et al. J. Cell Biol. 155(1):77-88(2001)Plant, P.J., et al. J. Cell Biol. 149(7):1473-1484(2000)

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$ 277.78
Cat# BP19526a
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