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TRIM22 Antibody(N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q8IYM9
Clone Names 100408311
Additional Information
Gene ID 10346
Other Names E3 ubiquitin-protein ligase TRIM22, 632-, 50 kDa-stimulated trans-acting factor, RING finger protein 94, Staf-50, Tripartite motif-containing protein 22, TRIM22, RNF94, STAF50
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM22
Synonyms RNF94, STAF50
Function Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22- dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
Cellular Location Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body Note=Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies
Tissue Location Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues
Research Areas
Citations (0)

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The protein encoded by this gene is a member of thetripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2,and a coiled-coil region. This protein localizes to the cytoplasmand its expression is induced by interferon. The proteindown-regulates transcription from the HIV-1 LTR promoter region,suggesting that function of this protein may be to mediateinterferon's antiviral effects.


Kajaste-Rudnitski, A., et al. Amino Acids 39(1):1-9(2010)Petersson, J., et al. Exp. Cell Res. 316(4):568-579(2010)Ovsyannikova, I.G., et al. Hum. Genet. 127(2):207-221(2010)Ovsyannikova, I.G., et al. J. Infect. Dis. 201(2):207-213(2010)Gao, B., et al. Hepatology 50(2):424-433(2009)

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$ 277.78
Cat# BP19529a
Availability: 2 weeks
Bulk Size

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