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GCFC Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y5B6
Clone Names 50908355
Additional Information
Gene ID 94104
Other Names PAX3- and PAX7-binding protein 1, GC-rich sequence DNA-binding factor 1, PAXBP1, C21orf66, GCFC, GCFC1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1953c was selected from the Center region of human GCFC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C21orf66, GCFC, GCFC1
Function Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20 (By similarity).
Cellular Location Nucleus.
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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Partial homology to a transcriptional repressor and histone-interacting protein suggests that GCFC is involved in the regulation of transcription. it GCFC binds to the GC-rich sequences (5'-gcggggc-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters.


Reymond, A., et al., Genomics 78 (1-2), 46-54 (2001).Slavov, D., et al., Gene 247 (1-2), 215-232 (2000).

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$ 277.78
Cat# BP1953c
Availability: 2 weeks
Bulk Size

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