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LONP1 Antibody(Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P36776
Clone Names 100318227
Additional Information
Gene ID 9361
Other Names Lon protease homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03120}, 3421- {ECO:0000255|HAMAP-Rule:MF_03120}, LONHs, Lon protease-like protein {ECO:0000255|HAMAP-Rule:MF_03120}, LONP {ECO:0000255|HAMAP-Rule:MF_03120}, Mitochondrial ATP-dependent protease Lon {ECO:0000255|HAMAP-Rule:MF_03120}, Serine protease 15 {ECO:0000255|HAMAP-Rule:MF_03120}, LONP1 {ECO:0000255|HAMAP-Rule:MF_03120}, PRSS15
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LONP1 {ECO:0000255|HAMAP-Rule:MF_03120}
Synonyms PRSS15
Function ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575).
Cellular Location Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03120, ECO:0000269|PubMed:7961901}
Tissue Location Duodenum, heart, lung and liver, but not thymus.
Research Areas
Citations (0)

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This gene encodes a mitochondrial matrix protein in theLon family of ATP-dependent proteases. A similar E. coli proteinregulates gene expression by targeting specific regulatory proteinsfor degradation. This protein binds a specific sequence in thelight and heavy chain promoters of the mitochondrial genome whichare involved in regulation of DNA replication and transcription.


Hansen, J., et al. Neuroscience 153(2):474-482(2008)Chen, S.H., et al. Nucleic Acids Res. 36(4):1273-1287(2008)Bogenhagen, D.F., et al. J. Biol. Chem. 283(6):3665-3675(2008)Bayot, A., et al. Biochimie 90(2):260-269(2008)Xue, X., et al. Nan Fang Yi Ke Da Xue Xue Bao 27(6):870-874(2007)

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$ 277.78
Cat# BP19551c
Availability: 2 weeks
Bulk Size

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