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Mouse Shc4 Antibody(C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6S5L9
Clone Names 110919147
Additional Information
Gene ID 271849
Other Names SHC-transforming protein 4, Rai-like protein, RaLP, SHC-transforming protein D, mShcD, Src homology 2 domain-containing-transforming protein C4, SH2 domain protein C4, Shc4, Shcd
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Shc4
Synonyms Shcd
Function Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Cellular Location Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction
Tissue Location Expressed in both brain and skeletal muscle; widely expressed in brain namely olfactory bulb, cortex, hippocampus, striatum, thalamus, and brain stem (at protein level). Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential
Research Areas
Citations (0)

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Background

Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.

References

Jones, N., et al. Mol. Cell. Biol. 27(13):4759-4773(2007)Fagiani, E., et al. Cancer Res. 67(7):3064-3073(2007)

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$ 277.78
Cat# BP19647b
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