|Other Names||F-box-like/WD repeat-containing protein TBL1Y, Transducin beta-like protein 1Y, Transducin-beta-like protein 1, Y-linked, TBL1Y, TBL1|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity).|
|Tissue Location||Fetal brain and prostate. Expressed in the cochlear spiral ganglion neurons, and in outer and inner hair cells (PubMed:30341416).|
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The protein encoded by this gene has sequence similaritywith members of the WD40 repeat-containing protein family. The WD40group is a large family of proteins, which appear to have aregulatory function. It is believed that the WD40 repeats mediateprotein-protein interactions and members of the family are involvedin signal transduction, RNA processing, gene regulation, vesiculartrafficking, cytoskeletal assembly and may play a role in thecontrol of cytotypic differentiation. This gene is highly similarto TBL1X gene in nucleotide sequence and protein sequence, but theTBL1X gene is located on chromosome X and this gene is onchromosome Y. This gene has three alternatively spliced transcriptvariants encoding the same protein.
Serajee, F.J., et al. J. Child Neurol. 24(10):1258-1261(2009)Russo, P., et al. Arterioscler. Thromb. Vasc. Biol. 28(8):1569-1574(2008)Agate, R.J., et al. Mol. Biol. Evol. 21(2):384-396(2004)Skaletsky, H., et al. Nature 423(6942):825-837(2003)
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