|Other Names||Synapsin-3, Synapsin III, SYN3|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the regulation of neurotransmitter release and synaptogenesis.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side Note=Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles|
|Tissue Location||Neuron specific. Detected predominantly in brain.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the synapsin gene family.Synapsins encode neuronal phosphoproteins which associate with thecytoplasmic surface of synaptic vesicles. Family members arecharacterized by common protein domains, and they are implicated insynaptogenesis and the modulation of neurotransmitter release,suggesting a potential role in several neuropsychiatric diseases.The protein encoded by this gene shares the synapsin family domainmodel, with domains A, C, and E exhibiting the highest degree ofconservation. The protein contains a unique domain J, locatedbetween domains C and E. Based on this gene's localization to22q12.3, a possible schizophrenia susceptibility locus, and theestablished neurobiological roles of the synapsins, this familymember may represent a candidate gene for schizophrenia. The TIMP3gene is located within an intron of this gene and is transcribed inthe opposite direction. Alternative splicing of this gene resultsin multiple splice variants that encode different isoforms.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Martins-de-Souza, D., et al. J Psychiatr Res (2010) In press :Neale, B.M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7395-7400(2010)Chen, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7401-7406(2010)
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