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Rde-4 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession G5EBF5
Other Accession Q22617
Clone Names 6022401
Additional Information
Gene ID 176438
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1969a was selected from the N-term region of human Rde-4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name G5EBF5
Research Areas
Citations (0)
citation

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Background

Double-stranded (ds) RNA is a potent sequence-specific inhibitor of gene function. RNA interference (RNAi) is a cellular defense mechanism that uses double-stranded RNA (dsRNA) as a sequence-specific trigger to guide the degradation of homologous single-stranded RNAs. RNAi is a multistep process involving several proteins and at least one type of RNA intermediate, a population of small 21??5 nt RNAs (called siRNAs) that are initially derived from cleavage of the dsRNA trigger. Genetic studies have implicated several RNA interference-deficient (rde) family members in germline maintenance and development, and several simple loss of function mutants have been identified. Family members rde-1 and rde-4 are required for RNAi but are not essential for organismal viability. While rde-1 and rde-4 are distinct from other RNAi-deficient family members both both for their inability to mobilize transposons and lack of chromosome loss, each appears to have a distinct role in the interference mechanism. Evidence indicates that rde-4 is involved before or during production of siRNAs, whereas rde-1 acts after the siRNAs have been formed.

References

Tabara H, et al. Cell. 2002. 109(7):861-71. Parrish S,et al. RNA. 2001. 7(10):1397-402. Fagard M, et al. PNAS. 2000. 97(21):11650-4 Ketting RF, et al. Nature. 2000. 404(6775):296-8. Tabara H, et al. Cell. 1999. 99(2):123-32.

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$ 277.78
Cat# BP1969a
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Availability: 2 weeks
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