DCAMKL3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9C098 |
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Gene ID | 85443 |
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Other Names | Serine/threonine-protein kinase DCLK3, Doublecortin domain-containing protein 3C, Doublecortin-like and CAM kinase-like 3, Doublecortin-like kinase 3, DCLK3, DCAMKL3, DCDC3C, KIAA1765 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1975c was selected from the Center region of human DCAMKL3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DCLK3 |
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Synonyms | DCAMKL3, DCDC3C, KIAA1765 |
Cellular Location | Cytoplasm. Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
A predominant CaMK subfamily, the CaMKI/CaMKIV family, is thought to play a significant role in the central nervous system. The CaMKIV-related kinases, doublecortin and CaM kinase-Like (DCAMKL)1, DCAMKL2, and DCAMKL3, contain kinase domains with an intermediate homology not only to CaMKI/CaMKIV but also to CaMKII. The DCAMKL proteins are highly expressed in the central nervous system of mice, in a neuron-specific fashion. DCAMKL1 lacks the doublecortin-like domain (Dx). In contrast, DCAMKL2 contains a full N-terminal Dx, while possesses only a partial and dysfunctional Dx. Despite a large similarity in the kinase domain, the DCAMKL proteins have an impact on CRE-dependent gene expression distinct from that of the related CaMKI/CaMKIV and CaMKII subfamilies.
References
Ohmae, S., et al. J Biol Chem. 2006. 281(29):20427-39.
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