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DCAMKL3 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9C098
Additional Information
Gene ID 85443
Other Names Serine/threonine-protein kinase DCLK3, Doublecortin domain-containing protein 3C, Doublecortin-like and CAM kinase-like 3, Doublecortin-like kinase 3, DCLK3, DCAMKL3, DCDC3C, KIAA1765
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1975c was selected from the Center region of human DCAMKL3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCLK3
Synonyms DCAMKL3, DCDC3C, KIAA1765
Cellular Location Cytoplasm. Nucleus.
Research Areas
Citations (0)

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Background

A predominant CaMK subfamily, the CaMKI/CaMKIV family, is thought to play a significant role in the central nervous system. The CaMKIV-related kinases, doublecortin and CaM kinase-Like (DCAMKL)1, DCAMKL2, and DCAMKL3, contain kinase domains with an intermediate homology not only to CaMKI/CaMKIV but also to CaMKII. The DCAMKL proteins are highly expressed in the central nervous system of mice, in a neuron-specific fashion. DCAMKL1 lacks the doublecortin-like domain (Dx). In contrast, DCAMKL2 contains a full N-terminal Dx, while possesses only a partial and dysfunctional Dx. Despite a large similarity in the kinase domain, the DCAMKL proteins have an impact on CRE-dependent gene expression distinct from that of the related CaMKI/CaMKIV and CaMKII subfamilies.

References

Ohmae, S., et al. J Biol Chem. 2006. 281(29):20427-39.

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$ 277.78
Cat# BP1975c
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