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HDBP2(HDRF-2) Antibody (Center) Blocking Peptide
Synthetic peptide
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- BACKGROUND
| Primary Accession | Q9H8N7 |
|---|---|
| Other Accession | NP_061130 |
| Clone Names | 6020666 |
| Other Names | Zinc finger protein 395, HD-regulating factor 2, HDRF-2, Huntington disease gene regulatory region-binding protein 2, HD gene regulatory region-binding protein 2, HDBP-2, Papillomavirus regulatory factor 1, PRF-1, Papillomavirus-binding factor, ZNF395, HDBP2, PBF |
|---|---|
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1979c was selected from the HDRF-2 region of human HDBP2(HDRF-2). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZNF395 |
|---|---|
| Synonyms | HDBP2, PBF |
| Function | Plays a role in papillomavirus genes transcription. |
| Cellular Location | Cytoplasm. Nucleus. Note=May shuttle between nucleus and cytoplasm |
| Tissue Location | Widely expressed. EMBL; AF263928; AAF73463.1; -; mRNA EMBL; AB044750; BAA96783.1; -; mRNA EMBL; AB044751; BAA96784.1; -; mRNA EMBL; AB044752; BAA96785.1; -; mRNA EMBL; AB057659; BAB39851.1; -; mRNA EMBL; AB073627; BAD29734.1; -; mRNA EMBL; AK002050; BAA92056.1; -; mRNA EMBL; AK023418; BAB14571.1; -; mRNA EMBL; AK098243; BAG53599.1; -; mRNA EMBL; CH471080; EAW63519.1; -; Genomic_DNA EMBL; CH471080; EAW63521.1; -; Genomic_DNA EMBL; CH471080; EAW63522.1; -; Genomic_DNA EMBL; CH471080; EAW63523.1; -; Genomic_DNA EMBL; CH471080; EAW63524.1; -; Genomic_DNA EMBL; BC001237; AAH01237.1; -; mRNA CCDS; CCDS6067.1; - RefSeq; NP_061130.1; NM_018660.2 SMR; Q9H8N7; - BioGRID; 120983; 7 IntAct; Q9H8N7; 5 MINT; Q9H8N7; - STRING; 9606.ENSP00000340494; - iPTMnet; Q9H8N7; - PhosphoSitePlus; Q9H8N7; - BioMuta; ZNF395; - DMDM; 84028224; - EPD; Q9H8N7; - jPOST; Q9H8N7; - MassIVE; Q9H8N7; - MaxQB; Q9H8N7; - PaxDb; Q9H8N7; - PeptideAtlas; Q9H8N7; - PRIDE; Q9H8N7; - ProteomicsDB; 81230; - Antibodypedia; 10391; 213 antibodies DNASU; 55893; - Ensembl; ENST00000344423; ENSP00000340494; ENSG00000186918 Ensembl; ENST00000523095; ENSP00000428452; ENSG00000186918 Ensembl; ENST00000523202; ENSP00000429640; ENSG00000186918 GeneID; 55893; - KEGG; hsa:55893; - UCSC; uc003xgq.4; human CTD; 55893; - DisGeNET; 55893; - EuPathDB; HostDB:ENSG00000186918.13; - GeneCards; ZNF395; - HGNC; HGNC:18737; ZNF395 HPA; ENSG00000186918; Low tissue specificity MIM; 609494; gene neXtProt; NX_Q9H8N7; - OpenTargets; ENSG00000186918; - PharmGKB; PA134978145; - eggNOG; ENOG502QW7P; Eukaryota GeneTree; ENSGT00940000157136; - HOGENOM; CLU_032989_2_1_1; - InParanoid; Q9H8N7; - OMA; CCRVEEV; - OrthoDB; 915379at2759; - PhylomeDB; Q9H8N7; - TreeFam; TF326610; - PathwayCommons; Q9H8N7; - BioGRID-ORCS; 55893; 11 hits in 877 CRISPR screens ChiTaRS; ZNF395; human GenomeRNAi; 55893; - Pharos; Q9H8N7; Tbio PRO; PR:Q9H8N7; - Proteomes; UP000005640; Chromosome 8 RNAct; Q9H8N7; protein Bgee; ENSG00000186918; Expressed in amniotic fluid and 238 other tissues ExpressionAtlas; Q9H8N7; baseline and differential Genevisible; Q9H8N7; HS GO; GO:0005737; C:cytoplasm; IDA:UniProtKB GO; GO:0005829; C:cytosol; IDA:HPA GO; GO:0005654; C:nucleoplasm; IDA:HPA GO; GO:0005634; C:nucleus; IDA:UniProtKB GO; GO:0003677; F:DNA binding; IDA:UniProtKB GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl GO; GO:0006355; P:regulation of transcription, DNA-templated; IC:UniProtKB InterPro; IPR031940; DUF4772 InterPro; IPR013087; Znf_C2H2_type Pfam; PF15997; DUF4772; 1 PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1 PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1 1: Evidence at protein level; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger CHAIN 1..513 /note="Zinc finger protein 395" /id="PRO_0000047561" ZN_FING 280..305 /note="C2H2-type" /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" MOTIF 165..174 /note="Nuclear export signal" /evidence="ECO:0000255" MOD_RES 248 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:19690332" MOD_RES 376 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:24275569" MOD_RES 449 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:23186163" MUTAGEN 109 /note="L->A: No change in subcellular location; when associated with A-113." /evidence="ECO:0000269|PubMed:14625278" MUTAGEN 113 /note="L->A: No change in subcellular location; when associated with A-109." /evidence="ECO:0000269|PubMed:14625278" MUTAGEN 169 /note="M->A: No shuttle from the nucleus to the cytoplasm; when associated with A-172." /evidence="ECO:0000269|PubMed:14625278" MUTAGEN 172 /note="M->A: No shuttle from the nucleus to the cytoplasm; when associated with A-169." /evidence="ECO:0000269|PubMed:14625278" CONFLICT 140 /note="G -> R (in Ref. 2; BAA96783/BAD29734)" /evidence="ECO:0000305" CONFLICT 464 /note="L -> Q (in Ref. 3; BAB14571)" /evidence="ECO:0000305" SEQUENCE 513 AA; 54939 MW; 992990499E228EB8 CRC64; MASVLSRRLG KRSLLGARVL GPSASEGPSA APPSEPLLEG AAPQPFTTSD DTPCQEQPKE VLKAPSTSGL QQVAFQPGQK VYVWYGGQEC TGLVEQHSWM EGQVTVWLLE QKLQVCCRVE EVWLAELQGP CPQAPPLEPG AQALAYRPVS RNIDVPKRKS DAVEMDEMMA AMVLTSLSCS PVVQSPPGTE ANFSASRAAC DPWKESGDIS DSGSSTTSGH WSGSSGVSTP SPPHPQASPK YLGDAFGSPQ TDHGFETDPD PFLLDEPAPR KRKNSVKVMY KCLWPNCGKV LRSIVGIKRH VKALHLGDTV DSDQFKREED FYYTEVQLKE ESAAAAAAAA AGTPVPGTPT SEPAPTPSMT GLPLSALPPP LHKAQSSGPE HPGPESSLPS GALSKSAPGS FWHIQADHAY QALPSFQIPV SPHIYTSVSW AAAPSAACSL SPVRSRSLSF SEPQQPAPAM KSHLIVTSPP RAQSGARKAR GEAKKCRKVY GIEHRDQWCT ACRWKKACQR FLD |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Papillomavirus Regulatory Factor 1/HDBP2 is a novel transcription factor shuttling between nucleus and cytoplasm and binds to the specific GCCGGCG, which is an essential cis-element for Huntington's disease gene expression.
References
Tanaka,K., J. Biol. Chem. 279 (8), 7275-7286 (2004)
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$ 277.78
Cat# BP1979c
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