|Other Names||Zinc finger protein 219, ZNF219|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1982a was selected from the N-term region of human ZNF219. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG- 3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
ZNF219 is a member of the Kruppel-like zinc finger family that is involved in a diverse range of biological processes. ZNF219 is a 77-kDa nuclear protein containing nine sets of C2H2 zinc finger structures. It may be involved in transcriptional regulation, it functions as a transcriptional repressor for the HMGN1 promoter
Olsen,J.V., Cell 127 (3), 635-648 (2006)Paces-Fessy,M., Biochem. J. 378 (PT 2), 353-362 (2004)Sakai,T., DNA Res. 10 (4), 155-165 (2003)
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