|Other Names||Transcription factor AP-1, Activator protein 1, AP1, Proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39, JUN|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1984b was selected from the C-term region of human JUN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:10995748, PubMed:22083952). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).|
|Tissue Location||Expressed in the developing and adult prostate and prostate cancer cells.|
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Provided below are standard protocols that you may find useful for product applications.
JUN interacts directly with specific target DNA sequences to regulate gene expression.
Fujita,S., J. Mol. Biol. 378 (3), 492-504 (2008)Gan,X.Q., . Cell Biol. 180 (6), 1087-1100 (2008)Yogev,O., Cancer Res. 68 (5), 1398-1406 (2008)
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