NFE2L3 Blocking Peptide(C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y4A8 |
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Other Accession | NP_004280.5 |
Gene ID | 9603 |
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Other Names | Nuclear factor erythroid 2-related factor 3, NF-E2-related factor 3, NFE2-related factor 3, Nuclear factor, erythroid derived 2, like 3, NFE2L3, NRF3 |
Target/Specificity | The synthetic peptide sequence is selected from aa 681-694 of HUMAN NFE2L3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NFE2L3 |
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Synonyms | NRF3 |
Function | Activates erythroid-specific, globin gene expression. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. |
Tissue Location | Highly expressed in human placenta and also in B- cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Zhang, Y., et al. J. Biol. Chem. 284(5):3195-3210(2009)
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