TES Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UGI8 |
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Other Accession | Q2QLE3, Q90YH9, Q2YDE9, NP_690042.1, Q2QLB2, Q09YJ2 |
Gene ID | 26136 |
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Other Names | Testin, TESS, TES |
Target/Specificity | The synthetic peptide sequence is selected from aa 56-70 of HUMAN TES |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TES |
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Function | Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. |
Cellular Location | Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers |
Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. Multiple protein isoforms are encoded by transcript variants of this gene.
References
Qiu, H., et al. Cancer Sci. 101(5):1255-1260(2010)
Gunduz, E., et al. Arch. Otolaryngol. Head Neck Surg. 135(3):254-260(2009)
Zhong, Y., et al. Mol. Cell. Biochem. 320 (1-2), 85-92 (2009) :
Huang, W., et al. Ai Zheng 27(9):984-988(2008)
Boeda, B., et al. Mol. Cell 28(6):1071-1082(2007)
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