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FCRL3 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96P31 |
|---|---|
| Other Accession | NP_443171.2 |
| Gene ID | 115352 |
|---|---|
| Other Names | Fc receptor-like protein 3, FcR-like protein 3, FcRL3, Fc receptor homolog 3, FcRH3, IFGP family protein 3, hIFGP3, Immune receptor translocation-associated protein 3, SH2 domain-containing phosphatase anchor protein 2, CD307c, FCRL3, FCRH3, IFGP3, IRTA3, SPAP2 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 709-720 of HUMAN FCRL3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FCRL3 (HGNC:18506) |
|---|---|
| Function | Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation- induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T- cells (PubMed:19494275, PubMed:20190142). Acts as a human-specific epitope on the cell surface of oocytes (oolemma) and plays a role during sperm-egg adhesion and fusion (PubMed:36070373). Interacts with the IZUMO1-IZUMO1R/JUNO sperm-egg complex and replaces IZUMO1R/JUNO as IZUMO1 receptor during fertilization, thereby permitting species- specific gamete fusion (PubMed:36070373). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane. Note=Localized along the oolemma microvilli of unfertilized oocytes |
| Tissue Location | Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Low expression on transitional B cells which increases to higher surface expression on mature and memory B- cells with innate-like features (at protein level) (PubMed:23857366) Expressed a low levels in naive and germinal center B-cells but also expressed in NK cells (at protein level) (PubMed:20190142). Expressed in unfertilized oocytes (at protein level) (PubMed:36070373). Expressed in a population of thymically derived naturally occurring regulatory T- cells that exhibits a memory phenotype, specialized in suppressing immune response to self-antigens (PubMed:20190142). Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.
References
Wu, H., et al. Hum. Immunol. (2010) In press :
Swainson, L.A., et al. J. Immunol. 184(7):3639-3647(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Zheng, R., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26(6):681-685(2009)
Gibson, A.W., et al. Arthritis Rheum. 60(11):3510-3512(2009)
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