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PDE8B Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95263 |
|---|---|
| Other Accession | E9Q4S1, NP_003710.1 |
| Gene ID | 8622 |
|---|---|
| Other Names | High affinity cAMP-specific and IBMX-insensitive 3', 5'-cyclic phosphodiesterase 8B, HsPDE8B, Cell proliferation-inducing gene 22 protein, PDE8B |
| Target/Specificity | The synthetic peptide sequence is selected from aa 311-324 of HUMAN PDE8B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PDE8B |
|---|---|
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. |
| Tissue Location | Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed In the placenta isoforms 1 and 2 are expressed equally. In the brain isoform 2 predominates. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.
References
Horvath, A., et al. Thyroid 20(4):363-367(2010)
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Appenzeller, S., et al. Am. J. Hum. Genet. 86(1):83-87(2010)
Shields, B.M., et al. J. Clin. Endocrinol. Metab. 94(11):4608-4612(2009)
Bimpaki, E.I., et al. Eur. J. Endocrinol. 161(1):153-161(2009)
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