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GFAP Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P14136 |
|---|---|
| Other Accession | NP_002046 |
| Clone Names | 2120406 |
| Gene ID | 2670 |
|---|---|
| Other Names | Glial fibrillary acidic protein, GFAP, GFAP |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2017a was selected from the N-term region of human GFAP . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GFAP |
|---|---|
| Function | GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
| Cellular Location | Cytoplasm. Note=Associated with intermediate filaments |
| Tissue Location | Expressed in cells lacking fibronectin. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GFAP is one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system.
References
Quintanar, J.L., et al., Parasitol. Res. 90(4):261-263 (2003).Shiroma, N., et al., Brain Dev. 25(2):116-121 (2003).Nielsen, A.L., et al., J. Biol. Chem. 277(33):29983-29991 (2002).Namekawa, M., et al., Ann. Neurol. 52(6):779-785 (2002).Lopez-Egido, J., et al., Exp. Cell Res. 278(2):175-183 (2002).
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