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Neurogenin2 Antibody (C-term) Blocking Peptide
Synthetic peptide
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| Primary Accession | Q9H2A3 |
|---|---|
| Clone Names | 2120602 |
| Other Names | Neurogenin-2, NGN-2, Class A basic helix-loop-helix protein 8, bHLHa8, Protein atonal homolog 4, NEUROG2, ATOH4, BHLHA8, NGN2 |
|---|---|
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2023b was selected from the C-term region of human Neurogenin2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NEUROG2 |
|---|---|
| Synonyms | ATOH4, BHLHA8, NGN2 |
| Function | Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3'). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. EMBL; BC036847; AAH36847.1; -; mRNA EMBL; AF303002; AAG40770.1; -; Genomic_DNA CCDS; CCDS3698.1; - RefSeq; NP_076924.1; NM_024019.3 SMR; Q9H2A3; - BioGRID; 122020; 3 IntAct; Q9H2A3; 2 MINT; Q9H2A3; - STRING; 9606.ENSP00000317333; - iPTMnet; Q9H2A3; - PhosphoSitePlus; Q9H2A3; - BioMuta; NEUROG2; - DMDM; 60392832; - PaxDb; Q9H2A3; - PRIDE; Q9H2A3; - ProteomicsDB; 80519; - Antibodypedia; 26453; 339 antibodies Ensembl; ENST00000313341; ENSP00000317333; ENSG00000178403 GeneID; 63973; - KEGG; hsa:63973; - UCSC; uc003ias.3; human CTD; 63973; - DisGeNET; 63973; - EuPathDB; HostDB:ENSG00000178403.3; - GeneCards; NEUROG2; - HGNC; HGNC:13805; NEUROG2 HPA; ENSG00000178403; Tissue enhanced (brain, testis) MIM; 606624; gene neXtProt; NX_Q9H2A3; - OpenTargets; ENSG00000178403; - PharmGKB; PA31570; - eggNOG; KOG3898; Eukaryota GeneTree; ENSGT00940000162895; - HOGENOM; CLU_097959_0_0_1; - InParanoid; Q9H2A3; - KO; K09082; - OMA; GLVHECK; - OrthoDB; 1524429at2759; - PhylomeDB; Q9H2A3; - TreeFam; TF315153; - PathwayCommons; Q9H2A3; - SIGNOR; Q9H2A3; - BioGRID-ORCS; 63973; 4 hits in 895 CRISPR screens GeneWiki; NEUROG2; - GenomeRNAi; 63973; - Pharos; Q9H2A3; Tbio PRO; PR:Q9H2A3; - Proteomes; UP000005640; Chromosome 4 RNAct; Q9H2A3; protein Bgee; ENSG00000178403; Expressed in subventricular zone (outer) (primate) and 39 other tissues Genevisible; Q9H2A3; HS GO; GO:0000790; C:nuclear chromatin; ISA:NTNU_SB GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB GO; GO:0070888; F:E-box binding; ISS:UniProtKB GO; GO:0046983; F:protein dimerization activity; IEA:InterPro GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL GO; GO:0030182; P:neuron differentiation; IEA:InterPro GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISS:UniProtKB CDD; cd00083; HLH; 1 Gene3D; 4.10.280.10; -; 1 InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf InterPro; IPR032655; Ngn2 PANTHER; PTHR19290:SF105; PTHR19290:SF105; 1 Pfam; PF00010; HLH; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 1: Evidence at protein level; Activator; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1..272 /note="Neurogenin-2" /id="PRO_0000127400" DOMAIN 112..164 /note="bHLH" /evidence="ECO:0000255|PROSITE-ProRule:PRU00981" COMPBIAS 198..246 /note="Ser-rich" SEQUENCE 272 AA; 28621 MW; 57AB37CC4A9E15FC CRC64; MFVKSETLEL KEEEDVLVLL GSASPALAAL TPLSSSADEE EEEEPGASGG ARRQRGAEAG QGARGGVAAG AEGCRPARLL GLVHDCKRRP SRARAVSRGA KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK IETLRFAHNY IWALTETLRL ADHCGGGGGG LPGALFSEAV LLSPGGASAA LSSSGDSPSP ASTWSCTNSP APSSSVSSNS TSPYSCTLSP ASPAGSDMDY WQPPPPDKHR YAPHLPIARD CI |
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Provided below are standard protocols that you may find useful for product applications.
Background
Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis from migratory neural crest cells. In the course of mouse neurogenesis, Ngn2 and Ngn1 are expressed in distinct progenitor populations residing in the central and peripheral nervous systems. Mutation analyses demonstrate that Ngn1 is required for the determination of neuronal precursors for proximal cranial sensory ganglia and that Ngn2 is necessary for the determination of precursors for epibranchial placode-derived sensory neurons.
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