|Other Names||Teratocarcinoma-derived growth factor 1, Cripto-1 growth factor, CRGF, Epidermal growth factor-like cripto protein CR1, TDGF1, CRIPTO|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2047a was selected from the N-term region of human TDGF1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953).|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Released from the cell membrane by GPI cleavage.|
|Tissue Location||Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.|
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Provided below are standard protocols that you may find useful for product applications.
TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers. This protein could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. It is preferentially expressed in gastric and colorectal carcinomas compared to their normal counterparts.
Parisi, S., et al., J. Cell Biol. 163(2):303-314 (2003).Gray, P.C., et al., Proc. Natl. Acad. Sci. U.S.A. 100(9):5193-5198 (2003).Yan, Y.T., et al., Mol. Cell. Biol. 22(13):4439-4449 (2002).de la Cruz, J.M., et al., Hum. Genet. 110(5):422-428 (2002).Dono, R., et al., Am. J. Hum. Genet. 49(3):555-565 (1991).
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