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PKP4 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q99569 |
|---|
| Gene ID | 8502 |
|---|---|
| Other Names | Plakophilin-4, p0071, PKP4 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 1055-1068 of Human PKP4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PKP4 |
|---|---|
| Function | Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques. |
| Cellular Location | Cell junction, desmosome. Cytoplasm, cytoskeleton, spindle. Midbody Cell membrane; Peripheral membrane protein. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells |
| Tissue Location | Expressed in salivary glands (at protein level) (PubMed:30479852). Expressed in arrector pili muscle (at protein level) (PubMed:29034528). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
References
Hatzfeld M., et al. J. Cell Sci. 109:2767-2778(1996).
Hillier L.W., et al. Nature 434:724-731(2005).
Salomon A.R., et al. Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003).
Zhang Y., et al. Mol. Cell. Proteomics 4:1240-1250(2005).
Tao W.A., et al. Nat. Methods 2:591-598(2005).
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