GDF10 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P55107 |
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Other Accession | NP_004953 |
Clone Names | 90415068 |
Gene ID | 2662 |
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Other Names | Bone morphogenetic protein 3B, BMP-3B, Bone-inducing protein, BIP, Growth/differentiation factor 10, GDF-10, GDF10, BMP3B |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP2060c was selected from the Center region of human GDF10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GDF10 (HGNC:4215) |
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Synonyms | BMP3B |
Function | Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis. |
Cellular Location | Secreted {ECO:0000250|UniProtKB:P97737}. |
Tissue Location | Expressed in femur, brain, lung, skeletal muscle, pancreas and testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GDF10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis.
References
Ducy, P., et al., Kidney Int. 57(6):2207-2214 (2000).Hino, J., et al., Biochem. Biophys. Res. Commun. 223(2):304-310 (1996).Cunningham, N.S., et al., Growth Factors 12(2):99-109 (1995).
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