PIP4K2C Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8TBX8 |
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Other Accession | O88370, Q91XU3, Q0P5F7 |
Gene ID | 79837 |
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Other Names | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma, Phosphatidylinositol 5-phosphate 4-kinase type II gamma, PI(5)P 4-kinase type II gamma, PIP4KII-gamma, PIP4K2C, PIP5K2C |
Target/Specificity | The synthetic peptide sequence is selected from aa 23-37 of HUMAN PIP4K2C |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PIP4K2C (HGNC:23786) |
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Synonyms | PIP5K2C |
Function | Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin- dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439). |
Cellular Location | Endoplasmic reticulum {ECO:0000250|UniProtKB:O88370}. Cytoplasm {ECO:0000250|UniProtKB:O88370} |
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Provided below are standard protocols that you may find useful for product applications.
Background
May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum (By similarity).
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Daub H.,et al.Mol. Cell 31:438-448(2008).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
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