|Other Names||Polycomb protein Suz12, Suppressor of zeste 12 protein homolog, Suz12, D11Ertd530e, Kiaa0160|
|Target/Specificity||The synthetic peptide sequence is selected from aa 381-395 of HUMAN Suz12|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED- EZH2 complex include HOXA7, HOXB6 and HOXC8.|
|Cellular Location||Nucleus. Chromosome. Note=Localizes to the inactive X chromosome in trophoblast stem cells|
|Tissue Location||Expressed in embryonic stem cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8.
Okazaki N.,et al.DNA Res. 10:35-48(2003).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Pasini D.,et al.EMBO J. 23:4061-4071(2004).
Umlauf D.,et al.Nat. Genet. 36:1296-1300(2004).
Kuzmichev A.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:1859-1864(2005).
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