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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   Mouse Neurog2 Blocking Peptide (C-term)   

Mouse Neurog2 Blocking Peptide (C-term)

Synthetic peptide

Product Information
Primary Accession P70447
Additional Information
Other Names Neurogenin-2, NGN-2, Helix-loop-helix protein mATH-4A, mATH4A, Protein atonal homolog 4, Neurog2, Ath4a, Atoh4, Ngn2
Target/Specificity The synthetic peptide sequence is selected from aa 247-262 of HUMAN Neurog2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Neurog2
Synonyms Ath4a, Atoh4, Ngn2
Function Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3').
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. EMBL; U76207; AAC53028.1; -; Genomic_DNA EMBL; Y07621; CAA68900.1; -; mRNA EMBL; AF303001; AAG40769.1; -; Genomic_DNA CCDS; CCDS17825.1; - RefSeq; NP_033848.1; NM_009718.2 SMR; P70447; - BioGRID; 198240; 5 STRING; 10090.ENSMUSP00000029587; - iPTMnet; P70447; - PhosphoSitePlus; P70447; - PaxDb; P70447; - PRIDE; P70447; - GeneID; 11924; - KEGG; mmu:11924; - CTD; 63973; - MGI; MGI:109619; Neurog2 eggNOG; KOG3898; Eukaryota InParanoid; P70447; - KO; K09082; - OrthoDB; 1524429at2759; - BioGRID-ORCS; 11924; 1 hit in 19 CRISPR screens PRO; PR:P70447; - Proteomes; UP000000589; Unplaced RNAct; P70447; protein GO; GO:0005634; C:nucleus; IDA:MGI GO; GO:0070888; F:E-box binding; IDA:UniProtKB GO; GO:0046983; F:protein dimerization activity; IEA:InterPro GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI GO; GO:0007411; P:axon guidance; IMP:MGI GO; GO:0045165; P:cell fate commitment; IGI:MGI GO; GO:0048469; P:cell maturation; IMP:MGI GO; GO:0021954; P:central nervous system neuron development; IMP:MGI GO; GO:0030900; P:forebrain development; IMP:MGI GO; GO:0022008; P:neurogenesis; IDA:MGI GO; GO:0030182; P:neuron differentiation; IMP:MGI GO; GO:0001764; P:neuron migration; IMP:MGI GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IDA:UniProtKB GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:MGI GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI CDD; cd00083; HLH; 1 DisProt; DP02061; - Gene3D;; -; 1 InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf InterPro; IPR032655; Ngn2 PANTHER; PTHR19290:SF105; PTHR19290:SF105; 1 Pfam; PF00010; HLH; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 1: Evidence at protein level; Activator; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1..263 /note="Neurogenin-2" /id="PRO_0000127401" DOMAIN 112..164 /note="bHLH" /evidence="ECO:0000255|PROSITE-ProRule:PRU00981" CONFLICT 60 /note="E -> G (in Ref. 2; CAA68900)" /evidence="ECO:0000305" SEQUENCE 263 AA; 28216 MW; 817EF8246BD8CABE CRC64; MFVKSETLEL KEEEEVLMLL GSASPASATL TPMSSSADEE EDEELRRPGS ARGQRGAEAE QGVQGSPASG AGGCRPGRLL GLMHECKRRP SRSRAVSRGA KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK IETLRFAHNY IWALTETLRL ADHCAGAGGL QGALFTEAVL LSPGAALGAS GDSPSPPSSW SCTNSPASSS NSTSPYSCTL SPASPGSDVD YWQPPPPEKH RYAPHLPLAR DCI
Research Areas
Citations (0)

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Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').


Sommer L.,et al.Mol. Cell. Neurosci. 8:221-241(1996).
Gradwohl G.,et al.Dev. Biol. 180:227-241(1996).
Simmons A.D.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
Lin C.H.,et al.Dev. Biol. 265:234-245(2004).

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$ 277.78
Cat# BP21257b
Availability: 2 weeks
Bulk Size

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