(Mouse) Jag1 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9QXX0 |
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Gene ID | 16449 |
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Other Names | Protein jagged-1, Jagged1, CD339, Jag1 |
Target/Specificity | The synthetic peptide sequence is selected from aa 1191-1204 of HUMAN Jag1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Jag1 |
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Function | Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis. |
Cellular Location | Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000250|UniProtKB:P78504} |
Tissue Location | Widely expressed in many tissues, with highest expression in brain, heart, muscle and thymus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis.
References
Shimizu K.,et al.J. Biol. Chem. 274:32961-32969(1999).
Loomes K.M.,et al.Hum. Mol. Genet. 8:2443-2449(1999).
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