TACR1 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P25103 |
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Gene ID | 6869 |
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Other Names | Substance-P receptor, SPR, NK-1 receptor, NK-1R, Tachykinin receptor 1, TACR1, NK1R, TAC1R |
Target/Specificity | The synthetic peptide sequence is selected from aa 363-377 of HUMAN TACR1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TACR1 |
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Synonyms | NK1R, TAC1R |
Function | This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
References
Takeda Y.,et al.Biochem. Biophys. Res. Commun. 179:1232-1240(1991).
Hopkins B.,et al.Biochem. Biophys. Res. Commun. 180:1110-1117(1991).
Gerard N.P.,et al.Biochemistry 30:10640-10646(1991).
Takahashi K.,et al.Eur. J. Biochem. 204:1025-1033(1992).
Fong T.M.,et al.Mol. Pharmacol. 41:24-30(1992).
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