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SUZ12 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q15022
Additional Information
Gene ID 23512
Other Names Polycomb protein SUZ12, Chromatin precipitated E2F target 9 protein, ChET 9 protein, Joined to JAZF1 protein, Suppressor of zeste 12 protein homolog, SUZ12, CHET9, JJAZ1, KIAA0160
Target/Specificity The synthetic peptide sequence is selected from aa 375-388 of HUMAN SUZ12
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SUZ12
Synonyms CHET9, JJAZ1, KIAA0160
Function Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557).
Cellular Location Nucleus Note=Localizes to chromatin as part of the PRC2 complex
Tissue Location Overexpressed in breast and colon cancer.
Research Areas
Citations (0)
citation

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Background

Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

References

Nagase T.,et al.DNA Res. 2:167-174(1995).
Koontz J.I.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:6348-6353(2001).
Weinmann A.S.,et al.Mol. Cell. Biol. 21:6820-6832(2001).
Kuzmichev A.,et al.Genes Dev. 16:2893-2905(2002).
Cao R.,et al.Science 298:1039-1043(2002).

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$ 277.78
Cat# BP21396c
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