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Mouse Erbb3 Blocking Peptide (P1076)

Synthetic peptide

     
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Product Information
Primary Accession Q61526
Additional Information
Gene ID 13867
Other Names Receptor tyrosine-protein kinase erbB-3, Glial growth factor receptor, Proto-oncogene-like protein c-ErbB-3, Erbb3
Target/Specificity The synthetic peptide sequence is selected from aa 1076-1090 of HUMAN Erbb3
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Erbb3
Function Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location In the muscle, expression localizes to the synaptic sites of muscle fibers
Research Areas
Citations (0)
citation

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Background

Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.

References

Yamauchi J.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
Moscoso L.M.,et al.Dev. Biol. 172:158-169(1995).
Kwon H.S.,et al.J. Biol. Chem. 288:26357-26371(2013).

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$ 277.78
Cat# BP21398a
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