|Other Names||Receptor tyrosine-protein kinase erbB-3, Glial growth factor receptor, Proto-oncogene-like protein c-ErbB-3, Erbb3|
|Target/Specificity||The synthetic peptide sequence is selected from aa 1076-1090 of HUMAN Erbb3|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||In the muscle, expression localizes to the synaptic sites of muscle fibers|
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Provided below are standard protocols that you may find useful for product applications.
Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.
Yamauchi J.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
Moscoso L.M.,et al.Dev. Biol. 172:158-169(1995).
Kwon H.S.,et al.J. Biol. Chem. 288:26357-26371(2013).
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