PLXNB1 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O43157 |
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Gene ID | 5364 |
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Other Names | Plexin-B1, Semaphorin receptor SEP, PLXNB1, KIAA0407, PLXN5, SEP |
Target/Specificity | The synthetic peptide sequence is selected from aa 1715-1729 of HUMAN PLXNB1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PLXNB1 |
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Synonyms | KIAA0407, PLXN5, SEP |
Function | Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496). |
Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 3]: Secreted |
Tissue Location | Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver |
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Background
Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
References
Ishikawa K.,et al.DNA Res. 4:307-313(1997).
Tamagnone L.,et al.Cell 99:71-80(1999).
Tamagnone L.,et al.Cell 104:321-321(2001).
Maestrini E.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:674-678(1996).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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