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(Mouse) Mlf1 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9QWV4 |
|---|
| Gene ID | 17349 |
|---|---|
| Other Names | Myeloid leukemia factor 1, Hematopoietic lineage switch 7, Myelodysplasia-myeloid leukemia factor 1, Mlf1, Hls7 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 91-106 of HUMAN Mlf1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Mlf1 |
|---|---|
| Synonyms | Hls7 |
| Function | Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. |
| Cellular Location | Cytoplasm. Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Shuttles between the cytoplasm and nucleus. |
| Tissue Location | Highly expressed in skeletal muscle, heart, testis. Also found in lung, but not in spleen, thymus, bone marrow, liver and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
References
Hitzler J.K.,et al.Am. J. Pathol. 155:53-59(1999).
Williams J.H.,et al.EMBO J. 18:5559-5566(1999).
Lim R.,et al.J. Biol. Chem. 277:40997-41008(2002).
Winteringham L.N.,et al.Oncogene 23:5105-5109(2004).
Winteringham L.N.,et al.J. Biol. Chem. 281:38791-38800(2006).
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