|Other Names||Rab11 family-interacting protein 5, Rab11-FIP5, Gamma-SNAP-associated factor 1, Gaf-1, Phosphoprotein pp75, Rab11-interacting protein Rip11, RAB11FIP5, GAF1, KIAA0857, RIP11|
|Target/Specificity||The synthetic peptide sequence is selected from aa 341-355 of HUMAN RAB11FIP5|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GAF1, KIAA0857, RIP11|
|Function||Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.|
|Cellular Location||Cytoplasm. Recycling endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein|
|Tissue Location||Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.
Prekeris R.,et al.Mol. Cell 6:1437-1448(2000).
Nagase T.,et al.DNA Res. 5:355-364(1998).
Wang D.,et al.J. Clin. Invest. 104:1265-1275(1999).
Chen D.,et al.J. Biol. Chem. 276:13127-13135(2001).
Wallace D.M.,et al.Biochem. Biophys. Res. Commun. 299:770-779(2002).
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