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SH3GL2 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q99962
Additional Information
Gene ID 6456
Other Names Endophilin-A1, EEN-B1, Endophilin-1, SH3 domain protein 2A, SH3 domain-containing GRB2-like protein 2, SH3GL2, CNSA2, SH3D2A
Target/Specificity The synthetic peptide sequence is selected from aa 127-138 of HUMAN SH3GL2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SH3GL2
Synonyms CNSA2, SH3D2A
Function Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:O35179}. Membrane {ECO:0000250|UniProtKB:O35179}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35179}. Early endosome {ECO:0000250|UniProtKB:Q62420}. Presynapse {ECO:0000250|UniProtKB:O35179}
Tissue Location Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum
Research Areas
Citations (0)
citation

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Background

Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.

References

Giachino C.,et al.Genomics 41:427-434(1997).
So C.W.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 277.78
Cat# BP21451c
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