XRN1 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8IZH2 |
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Gene ID | 54464 |
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Other Names | 5'-3' exoribonuclease 1, 3113-, Strand-exchange protein 1 homolog, XRN1, SEP1 |
Target/Specificity | The synthetic peptide sequence is selected from aa 1389-1403 of HUMAN XRN1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | XRN1 (HGNC:30654) |
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Function | Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). |
Cellular Location | Cytoplasm. Note=Discrete foci at the inner surface of the cell membrane |
Tissue Location | Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).
References
Shimoyama Y.,et al.Neuroscience 121:899-906(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Sato Y.,et al.DNA Res. 5:241-246(1998).
Lejeune F.,et al.Mol. Cell 12:675-687(2003).
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