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CASC5 Blocking Peptide (C-Term)

Synthetic peptide

     
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Product Information
Primary Accession Q8NG31
Additional Information
Gene ID 57082
Other Names Protein CASC5, ALL1-fused gene from chromosome 15q14 protein, AF15q14, Bub-linking kinetochore protein, Blinkin, Cancer susceptibility candidate gene 5 protein, Cancer/testis antigen 29, CT29, Kinetochore-null protein 1, Protein D40/AF15q14, CASC5, KIAA1570, KNL1
Target/Specificity The synthetic peptide sequence is selected from aa 2324-2337 of HUMAN CASC5
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KNL1 (HGNC:24054)
Synonyms CASC5, KIAA1570
Function Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.
Cellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle
Tissue Location Highly expressed in testis, where it is localized in germ cells, in particular in spermatocytes and in the pre-acrosome of round spermatids. Detected in the acrosome of ejaculated spermatozoa. Detected in adult thymus, bone marrow, colon, small intestine, appendix and placenta, and in fetal liver and thymus
Research Areas
Citations (0)

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Background

Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.

References

Hayette S.,et al.Oncogene 19:4446-4450(2000).
Takimoto M.,et al.Br. J. Cancer 86:1757-1762(2002).
Kuefer M.U.,et al.Oncogene 22:1418-1424(2003).
Zody M.C.,et al.Nature 440:671-675(2006).
Nagase T.,et al.DNA Res. 7:273-281(2000).

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$ 277.78
Cat# BP21540b
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