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SLC5A4 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NY91 |
|---|
| Gene ID | 6527 |
|---|---|
| Other Names | Low affinity sodium-glucose cotransporter, Sodium/glucose cotransporter 3, Na(+)/glucose cotransporter 3, Solute carrier family 5 member 4, SLC5A4, SAAT1, SGLT2 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 621-635 of HUMAN SLC5A4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC5A4 {ECO:0000303|PubMed:13130073} |
|---|---|
| Function | Does not function as sodium/D-glucose symporter (PubMed:13130073, PubMed:20421923, PubMed:22766068). However, may function as a D-glucose sensor by generating a D-glucose-induced depolarization which is pH-independent, Na(+)-dependent at neutral pH and probably H(+)-dependent at acidic pH (PubMed:13130073, PubMed:22766068, PubMed:17110502, PubMed:20421923). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in skeletal muscle, where it may localize to the neuromuscular junction (at protein level) (PubMed:13130073) Expressed in small intestine where it may localize to cholinergic neurons of the submucosal plexus and myenteric plexus (at protein level) (PubMed:13130073). Detected in kidney (at protein level) (PubMed:22766068). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Sodium-dependent glucose transporter.
References
Gorboulev V.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
Dunham I.,et al.Nature 402:489-495(1999).
Poppe R.,et al.Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
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