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RNF7 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q9UBF6
Additional Information
Gene ID 9616
Other Names RING-box protein 2, Rbx2, CKII beta-binding protein 1, CKBBP1, RING finger protein 7, Regulator of cullins 2, Sensitive to apoptosis gene protein, RNF7, RBX2, ROC2, SAG
Target/Specificity The synthetic peptide sequence is selected from aa 25-37 of HUMAN RNF7
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF7
Synonyms RBX2, ROC2, SAG
Function Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING- type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.
Cellular Location Cytoplasm. Nucleus
Tissue Location Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung
Research Areas
Citations (0)
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Background

Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.

References

Son M.-Y.,et al.Biochem. Biophys. Res. Commun. 263:743-748(1999).
Ohta T.,et al.Mol. Cell 3:535-541(1999).
Duan H.,et al.Mol. Cell. Biol. 19:3145-3155(1999).
Swaroop M.,et al.DNA Cell Biol. 20:425-434(2001).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 277.78
Cat# BP21564a
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