GFRA1 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P56159 |
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Gene ID | 2674 |
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Other Names | GDNF family receptor alpha-1, GDNF receptor alpha-1, GDNFR-alpha-1, GFR-alpha-1, RET ligand 1, TGF-beta-related neurotrophic factor receptor 1, GFRA1, GDNFRA, RETL1, TRNR1 |
Target/Specificity | The synthetic peptide sequence is selected from aa 381-395 of HUMAN GFRA1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GFRA1 |
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Synonyms | GDNFRA, RETL1, TRNR1 |
Function | Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q62997}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q62997}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q62997}. Endosome {ECO:0000250|UniProtKB:Q62997}. Endosome, multivesicular body {ECO:0000250|UniProtKB:Q62997}. Note=Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies {ECO:0000250|UniProtKB:Q62997} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).
References
Jing S.,et al.Cell 85:1113-1124(1996).
Sanicola M.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:6238-6243(1997).
Angrist M.,et al.Genomics 48:354-362(1998).
Shefelbine S.E.,et al.Hum. Genet. 102:474-478(1998).
Hishiki T.,et al.Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
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